Folate Metabolism RT PCR Genotyping Kit

GENERAL INFORMATION Disorders in the metabolism of folic acid are the cause of the development of various pathological processes: cardiovascular diseases, complications during pregnancy, fetal malformations, etc. Genetic polymorphisms in the genes responsible for the synthesis of enzymes involved in the folate cycle are a predisposing component for the development of some diseases. Folate Metabolism Real-Time PCR Genotyping Kit (4 SNPs) enables the detection of 4 polymorphisms associated with folate metabolism disorders: MTHFR: 677 C>T (Ala222Val) MTHFR: 1298 A>C (Glu429Ala) MTR: 2756 A>G (Asp919Gly) MTRR: 66 A>G (lle22Met) FEATURES AND BENEFITS High specificity of detection of the studied polymorphisms by conducting Real-Time PCR and subsequent analysis of melting curves (melting curve analysis) An endogenous control was included to assess the quality of the clinical material and the DNA extraction process CE-IVD certified